Ionizing radiation damage and repair from 3D-genomic perspective
Yang Zheng, Hao Li, Xiaochen Bo, Hebing Chen
Abstract
Ionizing radiation (IR)-induced DNA damage and repair are complex and occur at hierarchical chromatin structures; radiobiology needs to be studied from a 3D-genomic perspective. Differences in IR damage and repair throughout the 3D genome may help to explain differences in radiosensitivity. Ionizing radiation (IR)-induced DNA damage and repair are complex and occur at hierarchical chromatin structures; radiobiology needs to be studied from a 3D-genomic perspective. Differences in IR damage and repair throughout the 3D genome may help to explain differences in radiosensitivity.
Topics & Concepts
BiologyIonizing radiationChromatinRadiosensitivityDNA damageDNA repairRadiobiologyComputational biologyGenomeGeneticsPerspective (graphical)DNAEvolutionary biologyIrradiationGeneComputer sciencePhysicsNuclear physicsArtificial intelligenceDNA Repair MechanismsGenomics and Chromatin DynamicsPlant Genetic and Mutation Studies