LWJ-M30, a conjugate of DM1 and B6, for the targeted therapy of colorectal cancer with improved therapeutic effects
Qiu-Yan Zhang, Qing-Long Yu, Wei-Jing Luan, Tong-Fang Li, Ya-Ni Xiao, Li Zhang, Yi Li, Rong Rong, Chunguang Ren
Abstract
demonstrated that LWJ-M30 could inhibit the HCT116 growth without affecting the mouse body weight. Taking these results together, our data indicated that LWJ-M30 could improve the therapeutic effects of DM1 while reducing the systemic toxicity in normal tissues.
Topics & Concepts
ConjugateColorectal cancerMedicineOncologyTherapeutic effectCancerCancer therapyInternal medicineCancer researchMathematicsMathematical analysisPeptidase Inhibition and AnalysisRadiopharmaceutical Chemistry and ApplicationsCancer Research and Treatments