Non-motor complications in late stage Parkinson’s disease: recognition, management and unmet needs
Katarina Rukavina, Lucia Batzu, Alexandra Boogers, Arturo Abundes‐Corona, Verónica Bruno, К. Ray Chaudhuri
Abstract
: The NMS progression pattern is complex and remains under-researched. While dopamine-dependent NMS may improve with dopamine replacement therapy, non-dopamine dependent NMS worsen progressively and culminate at the late stages of PD. Furthermore, some PD specific features could interact negatively with other comorbidities, multiple medication use and frailty - the evaluation of these aspects is important in the creation of personalized management plans in the late stage of PD.
Topics & Concepts
Parkinson's diseaseDysautonomiaMedicineDopaminergicProdromal StageDopamineDiseasePhysical medicine and rehabilitationQuality of life (healthcare)DementiaInternal medicineNursingParkinson's Disease Mechanisms and TreatmentsRestless Legs Syndrome ResearchNeurological disorders and treatments