<p>Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives</p>
Elton Jonh Freitas Santos, Raimunda Sheyla Carneiro Dias, Janielle Ferreira de Brito Lima, Natalino Salgado Filho, Alcione Miranda dos Santos
Abstract
Anemia is a frequent complication of chronic kidney disease, and its primary cause is erythropoietin deficiency. After diagnosis, treatment begins with administration of an erythropoiesis-stimulating agent (ESA). However, some patients present with resistance to ESA, which needs to be reversed, as it can increase the risk of death in patients with kidney disease. Therefore, we provide a discussion of the current literature regarding the factors that can modify the response to this class of drugs and the strategies that can be considered to optimize the benefits of treating anemia.
Topics & Concepts
MedicineErythropoietinKidney diseaseAnemiaErythropoiesisDiseaseIntensive care medicineKidneyInternal medicineErythropoietin and Anemia TreatmentHemoglobinopathies and Related DisordersIron Metabolism and Disorders