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Inhibition of the PI3K/AKT/mTOR signaling promotes an M1 macrophage switch by repressing the ATF3-CXCL8 axis in Ewing sarcoma

Ramona Palombo, Ilaria Passacantilli, Francesca Terracciano, Alessia Capone, Alessandro Matteocci, Simon Tournier, A. Alberdi, Valerio Chiurchiù, Elisabetta Volpe, Maria Paola Paronetto

2022Cancer Letters36 citationsDOI

Topics & Concepts

PI3K/AKT/mTOR pathwayProtein kinase BCancer researchATF3ChemokineBiologyProinflammatory cytokineTumor microenvironmentSignal transductionCell biologyImmunologyInflammationPromoterGene expressionTumor cellsGeneBiochemistryImmune cells in cancerCancer, Hypoxia, and MetabolismImmune Cell Function and Interaction
Inhibition of the PI3K/AKT/mTOR signaling promotes an M1 macrophage switch by repressing the ATF3-CXCL8 axis in Ewing sarcoma | Litcius