The gut microbiome contributes to splenomegaly and tissue inflammation in a murine model of primary biliary cholangitis
Chengbo Wang, Yan Wang, Yuan Yao, Jin‐Jun Wang, Koichi Tsuneyama, Qiong Yang, Bin Liu, Carlo Selmi, M. Eric Gershwin, Shuhan Yang, Zhe‐Xiong Lian
Abstract
Background: Splenomegaly is not just a consequence of numerous chronic and acute conditions but may also contribute to their severity, due to the interaction of the spleen with the gut microbiome. This study aimed to explore the effect of the gut microbiome on splenomegaly. Methods: mice. Results: mice, significantly alleviated liver inflammation, and caused a significant reduction of liver and spleen T cell accumulation and activation; however, single antibiotics did not induce these changes. Conclusions: Splenomegaly was associated with more severe liver inflammation in our PBC murine model, and this effect was reversed by quadruple antibiotic treatment.