Strategies to Potentiate Paracrine Therapeutic Efficacy of Mesenchymal Stem Cells in Inflammatory Diseases
Yoojin Seo, Min‐Jung Kang, Hyung‐Sik Kim
Abstract
Mesenchymal stem cells (MSCs) have been developed as cell therapeutics for various immune disorders using their immunoregulatory properties mainly exerted by their paracrine functions. However, variation among cells from different donors, as well as rapid clearance after transplantation have impaired the uniform efficacy of MSCs and limited their application. Recently, several strategies to overcome this limitation have been suggested and proven in pre-clinical settings. Therefore, in this review article, we will update the knowledge on bioengineering strategies to improve the immunomodulatory functions of MSCs, including genetic modification and physical engineering.
Topics & Concepts
Mesenchymal stem cellParacrine signallingImmune systemTransplantationStem cellMedicineImmunologyCancer researchBioinformaticsBiologyCell biologyPathologyInternal medicineReceptorMesenchymal stem cell researchRNA Interference and Gene DeliveryExtracellular vesicles in disease