Atroposelective Synthesis of N–N Axially Chiral Bipyrroles via Rhodium-Catalyzed C–H Insertion Reaction
Changkai Wang, Jiangtao Sun
Abstract
An atroposelective synthesis of bipyrroles with an axially chiral N-N bond has been established via a rhodium-catalyzed C-H bond insertion reaction to provide the desired atropisomers in good yields (up to 97% yield) with good to excellent enantioselectivities (up to 99% ee).
Topics & Concepts
AtropisomerChemistryRhodiumYield (engineering)CatalysisAxial symmetryInsertion reactionMedicinal chemistryCombinatorial chemistryReaction conditionsStereochemistryOrganic chemistryMetallurgyEngineeringMaterials scienceStructural engineeringAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralitySphingolipid Metabolism and Signaling