LincRNA-p21 knockdown reversed tumor-associated macrophages function by promoting MDM2 to antagonize* p53 activation and alleviate breast cancer development
Lining Zhou, Yu Tian, Fang Guo, Bin Yu, Jiali Li, Huaxi Xu, Zhaoliang Su
Topics & Concepts
Gene knockdownCancer researchTumor microenvironmentMacrophage polarizationBiologyMdm2Tumor progressionBreast cancerFlow cytometryImmune systemCancerMacrophageApoptosisImmunologyIn vitroTumor cellsGeneticsBiochemistryCancer-related molecular mechanisms researchImmune cells in cancerMicroRNA in disease regulation