The Caspofungin Paradoxical Effect is a Tolerant “Eagle Effect” in the Filamentous Fungal Pathogen <i>Aspergillus fumigatus</i>
Clara Valero, Ana Cristina Colabardini, Patrícia Alves de Castro, Jorge Amich, Michael Bromley, Gustavo H. Goldman
Abstract
The “Eagle effect,” initially described for bacterial species, which reflects the capacity of some strains to growth above the minimum inhibitory concentration (MIC) of specific antimicrobial agents, has been known for more than 70 years. However, its underlying mechanism of action in fungi is not fully understood and its connection with other phenomena such as tolerance or persistence is not clear yet.
Topics & Concepts
CaspofunginAspergillus fumigatusMicrobiologyBiologyConidiumPathogenAspergillosisAntifungalAmphotericin BImmunologyBotanyAntifungal resistance and susceptibilityFungal Biology and ApplicationsMicrobial Natural Products and Biosynthesis