Multi-target weapons: diaryl-pyrazoline thiazolidinediones simultaneously targeting VEGFR-2 and HDAC cancer hallmarks
Neha Upadhyay, Kalpana Tilekar, Sabreena Safuan, Alan Prem Kumar, Markus Schweipert, Franz‐Josef Meyer‐Almes, C. S. Ramaa
Abstract
could be a potential lead to develop more optimized multi-target analogs with enhanced potency and selectivity.
Topics & Concepts
In vivoChemistryProtein Data Bank (RCSB PDB)AngiogenesisCancer researchPotencyPharmacologyIn vitroCytotoxicityBiochemistryBiologyBiotechnologyHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsPeptidase Inhibition and Analysis