Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing
Hugo Bernard, Ana Teijeiro, Almudena Chaves Perez, Cristian Perna, Basanthi Satish, Anna Novials, Jennifer Wang, Nabil Djouder
Abstract
promoter hypermethylation and silencing. Consequently, demethylating agent procainamide-mediated DNMT1 inhibition reinstates PDX1 expression and protects against diabetes in pancreatic URI-depleted mice . Finally, the β cells of human diabetes patients show correlations between viral protein 1 and URI, PDX1, and DNMT1 levels. URI and DNMT1 expression and PDX1 silencing provide a causal link between enterovirus infection and diabetes.
Topics & Concepts
PDX1Gene silencingBiologyCoxsackievirusCell biologyCancer researchVirologyEndocrinologyDiabetes mellitusIsletEnterovirusVirusBiochemistryGenePancreatic function and diabetesDiabetes and associated disordersEndoplasmic Reticulum Stress and Disease