Functional knockout of ASIC3 attenuates the exercise pressor reflex in decerebrated rats with ligated femoral arteries
Joyce Kim, Guillaume P. Ducrocq, Marc P. Kaufman
Abstract
We used a genetic approach to test the hypothesis that the magnitude of the exercise pressor reflex evoked in ligated ASIC3 KO rats was significantly lower than the magnitude of the exercise pressor reflex evoked in their ligated wild-type (WT) counterparts. The pressor response to contraction in ligated ASIC3 KO rats was significantly smaller than was the pressor response to contraction in ligated WT rats.
Topics & Concepts
ReflexMedicineInternal medicineEndocrinologyCardiologyIon Transport and Channel RegulationNitric Oxide and Endothelin EffectsRenal function and acid-base balance