Widespread activation of developmental gene expression characterized by PRC1-dependent chromatin looping
Vincent Loubière, Giorgio L. Papadopoulos, Quentin Szabo, Anne‐Marie Martinez, Giacomo Cavalli
Abstract
locus indicates that PRC1-anchored loops are versatile architectural platforms that persist when surrounding genes are transcriptionally active and fine-tune their expression. The analysis of RING1B binding profiles and 3D contacts during neural differentiation in mice suggests that this role is conserved in mammals.
Topics & Concepts
ChromatinTranscription (linguistics)GeneGene expressionRegulation of gene expressionBiologyGeneticsComputational biologyTranscription factorCell biologyPhilosophyLinguisticsGenomics and Chromatin DynamicsEpigenetics and DNA MethylationGenomic variations and chromosomal abnormalities