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Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy

Man Li, Mengmeng Li, Yiliang Yang, Yingke Liu, Hanbing Xie, Qianwen Yu, Lifeng Tian, Xian Tang, Kebai Ren, Jianping Li, Zhirong Zhang, Qin He

2020Journal of Controlled Release224 citationsDOI

Topics & Concepts

Cancer researchPancreatic cancerTumor microenvironmentImmune systemImmunotherapyPI3K/AKT/mTOR pathwayPancreatic tumorCancer immunotherapyMedicineCancerChemistryImmunologySignal transductionBiologyInternal medicineCell biologyImmune cells in cancerPhagocytosis and Immune RegulationImmune Cell Function and Interaction
Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy | Litcius