Transcriptomic signatures of exacerbated progression in leptospirosis subclinical chronic kidney disease with secondary nephrotoxic injury
Li‐Fang Chou, Ting-Wen Chen, Huang‐Yu Yang, Ya‐Chung Tian, Ming‐Yang Chang, Cheng-Chieh Hung, Shen‐Hsing Hsu, Chung‐Ying Tsai, Yi-Ching Ko, Chih‐Wei Yang
Abstract
Leptospira-infected mice followed by secondary nephrotoxic injury exacerbated immune/inflammatory responses and renal fibrosis. Comparison with the murine model revealed candidates involved in the progression of renal fibrosis in chronic kidney disease (CKD). Comparative transcriptome study suggests that secondary nephrotoxic injury in Leptospira-infected mice recapitulates the gene expression signatures found in CKD patients. This study indicates that secondary nephrotoxic injury may exacerbate CKD in chronic Leptospira infection implicating in the progression of CKD of unknown etiology.
Topics & Concepts
NephrotoxicityKidney diseaseTranscriptomeLeptospiraFibrosisMedicineAcute kidney injurySubclinical infectionPathologyKidneyImmunologyLeptospirosisInternal medicineBiologyGene expressionGeneBiochemistryLeptospirosis research and findingsBiomarkers in Disease Mechanisms