Development of the “hidden” multi-target-directed ligands by AChE/BuChE for the treatment of Alzheimer's disease
Rui Chen, Xinjuan Li, Hongsong Chen, Keren Wang, Teng Xue, Jing Mi, Yujuan Ban, Gaofeng Zhu, Yi Zhou, Wu Dong, Lei Tang, Zhipei Sang
Topics & Concepts
ChemistryAchéPotencyIC50CarbamateNeuroprotectionPharmacologyChalconeChelationLead compoundIn vitroInhibitory postsynaptic potentialBiochemistryAcetylcholinesteraseEnzymeStereochemistryInternal medicineOrganic chemistryMedicineCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsComputational Drug Discovery Methods