Lactoferrin Is Broadly Active against Yeasts and Highly Synergistic with Amphotericin B
Kenya E. Fernandes, Kerry Weeks, Dee Carter
Abstract
Lactoferrin (LF) is a multifunctional milk protein with antimicrobial activity against a range of pathogens. While numerous studies report that LF is active against fungi, there are considerable differences in the level of antifungal activity and the capacity of LF to interact with other drugs. Here we undertook a comprehensive evaluation of the antifungal spectrum of activity of three defined sources of LF across 22 yeast and 24 mold species and assessed its interactions with six widely used antifungal drugs.
Topics & Concepts
LactoferrinAntimicrobialAntifungalMicrobiologyYeastAmphotericin BBiologyBiological activityBroad spectrumAntifungal drugsChemistryIn vitroBiochemistryCombinatorial chemistryInfant Nutrition and HealthBreastfeeding Practices and InfluencesCystic Fibrosis Research Advances