Mild and Regioselective Three‐component Heteroarylation‐Nitration of Alkenes with Imidazo[1,2‐<i>a</i>]pyridines and <i>tert</i>‐Butyl Nitrite
Jie Zhang, Shentong Xie, Ping Liu, Peipei Sun
Abstract
Abstract An efficient and regioselective three‐component heteroarylation‐nitration of alkenes with imidazo[1,2‐ a ]pyridines and tert ‐butyl nitrite has been developed. The process tolerants a variety of functional groups under mild conditions in the absence of catalysts and additives to give nitro functionalized imidazo[1,2‐ a ]pyridine derivatives in moderate to good yields. The reaction is also applicable for some other aza‐heterocycles. magnified image
Topics & Concepts
NitrationRegioselectivityChemistryNitritePyridineNitroCatalysisComponent (thermodynamics)Organic chemistryMedicinal chemistryCombinatorial chemistryNitrateAlkylThermodynamicsPhysicsCatalytic C–H Functionalization MethodsPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Catalytic Reactions