Exploring a solid-state nanopore approach for single-molecule protein detection from single cells
Ziqi Zhou, Shao-Chuang Liu, Jia Wang, Kele Chen, Bao-Kang Xie, Yi‐Lun Ying, Yi-Tao Long
Abstract
nanopores. Our results reveal significant differences between proteins measured directly from single cells and those obtained from purified samples. This work demonstrates the potential of solid-state nanopores as a powerful tool for single-cell, single-molecule protein analysis, opening avenues for investigating protein dynamics and interactions at the cellular level.
Topics & Concepts
NanoporeSolid-stateMoleculeSingle useState (computer science)Single-cell analysisChemistryNanotechnologyComputer scienceMaterials scienceBiochemistryEngineeringCellPhysical chemistryAlgorithmOrganic chemistryProcess engineeringNanopore and Nanochannel Transport StudiesAdvanced biosensing and bioanalysis techniquesIon-surface interactions and analysis