Mutation-based clustering and classification analysis reveals distinctive age groups and age-related biomarkers for glioma
Claire Jean-Quartier, Fleur Jeanquartier, Aydin Ridvan, Matthias Kargl, Tica Mirza, Tobias Stangl, Robi Markaĉ, Mauro Jurada, Andreas Holzinger
Abstract
BACKGROUND: Malignant brain tumor diseases exhibit differences within molecular features depending on the patient's age. METHODS: In this work, we use gene mutation data from public resources to explore age specifics about glioma. We use both an explainable clustering as well as classification approach to find and interpret age-based differences in brain tumor diseases. We estimate age clusters and correlate age specific biomarkers. RESULTS: Age group classification shows known age specifics but also points out several genes which, so far, have not been associated with glioma classification. CONCLUSIONS: We highlight mutated genes to be characteristic for certain age groups and suggest novel age-based biomarkers and targets.