Direct C−H Difluoroalkylation of Heteroarenes with Difluoroalkyl Carboxylic Acids
Chunfang Guo, Xuliang Han, Xiangye Li, Zhengzhen Diao, Xinjin Li, Yunhui Dong
Abstract
Abstract A new method for the difluoroalkylation of heteroaromatic compounds has been developed by employing readily available difluoroalkyl carboxylic acids. This silver‐catalyzed reaction proceeds under mild conditions and affords a broad range of difluoroalkylated heteroarenes in moderate to good yields, including pyridines, pyrimidines, pyrazines, quinolines, quinoxalines as well as bioactive compounds.
Topics & Concepts
ChemistryOrganic chemistryCombinatorial chemistryCatalysisReaction conditionsFluorine in Organic ChemistryInorganic Fluorides and Related Compounds