Development of STING degrader with double covalent ligands
Miki Nakamura, Nobumichi Ohoka, Norihito Shibata, Takao Inoué, Genichiro Tsuji, Yosuke Demizu
Topics & Concepts
StingStimulator of interferon genesChemistryEndoplasmic reticulumUbiquitin ligaseCovalent bondUbiquitinInnate immune systemLigand (biochemistry)ProteolysisReceptorCell biologyPharmacologyBiochemistryMedicineBiologyGeneEnzymeEngineeringOrganic chemistryAerospace engineeringinterferon and immune responsesUbiquitin and proteasome pathwaysNF-κB Signaling Pathways