Acellular human amniotic fluid protects the ischemic-reperfused rat myocardium
Young Sook Lee, Hadi Javan, Jo‐Anna Reems, Ling Li, Jessica Lusty Beech, Christine I. Schaaf, Jan Pierce, John D. Phillips, Craig H. Selzman
Abstract
Rather than targeting a single pathway implicated in myocardial reperfusion injury, cell-free human amniotic fluid-a naturally derived cocktail composed of thousands of proteins involved with innate immunity and anti-inflammation-markedly reduces injury and preserves cardiac function in a model of rodent myocardial ischemia-reperfusion. With its ubiquitous availability as well as its anti-inflammatory and nonimmunogenic properties, human cell-free amniotic fluid offers potential for use as a cardioprotective adjunct.
Topics & Concepts
MedicineCardioprotectionCardiologyReperfusion injuryIschemiaMyocardial infarctionInternal medicineCardiac Ischemia and ReperfusionCardiac Fibrosis and RemodelingTissue Engineering and Regenerative Medicine