Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia
Maria Camila González, Diego Tovar, Guido Alves, Ingvild Dalen, Caroline H. Williams‐Gray, Marta Camacho, Lars Forsgren, David Bäckström, Rachael Lawson, Angus D. Macleod, Carl Counsell, Claire Paquet, Carlo DeLena, Fabrizia D’Antonio, Andrea Pilotto, Alessandro Padovani, Frederic Blanc, Cristian Falup‐Pecurariu, Simon J.G. Lewis, Konrad Rejdak, Ewa Papuć, Jakub Hort, Zuzana Nedelská, John T. O’Brien, Laura Bonanni, Marta Marquié, Merçé Boada, Vanesa Pytel, Carla Abdelnour, Daniel Alcolea, Katrin Beyer, Ole‐Bjørn Tysnes, Dag Aarsland, Jodi Maple‐Grødem
Abstract
ABSTRACT Background There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E‐DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods The annual change in MMSE and MDS‐UPDRS part III was estimated using linear mixed regression models in patients with at least one follow‐up (DLB n = 837 and PDD n = 157). Results When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [ P = 0.74]). MDS‐UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [ P = 0.98]). Conclusions DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.