Autophagy promotes GSDME-mediated pyroptosis via intrinsic and extrinsic apoptotic pathways in cobalt chloride-induced hypoxia reoxygenation-acute kidney injury
Wenna Liu, Yujin Gan, Yun Ding, Lina Zhang, Xiaojing Jiao, Lu Liu, Huixia Cao, Yue Gu, Lei Yan, Yanliang Wang, Limeng Wang, Song Chen, Fengmin Shao
Abstract
-induced HRI-AKI and promoted the understanding of the regulatory mechanism of GSDME cleavage. Our study might provide a potential therapeutic target for HRI-AKI, and will be helpful for the risk evaluation of cobalt exposure.
Topics & Concepts
PyroptosisAutophagyProgrammed cell deathApoptosisCell biologyChemistryBiologyCancer researchBiochemistryHeme Oxygenase-1 and Carbon MonoxideAutophagy in Disease and TherapyInflammasome and immune disorders