Electrochemical synthesis of 1,2,4,5-tetrasubstituted imidazoles from enamines and benzylamines
Wenxing Wang, Shuo Zhang, Guang Shi, Zhiwei Chen
Abstract
An electrochemical method for synthesizing 1,2,4,5-tetrasubstituted imidazoles was developed under undivided electrolytic conditions. This synthesis was specifically realized based on electrochemical C(sp3)-H amination via enamines and amines. Readily available starting materials were used, avoiding the use of both transition metals and oxidants. The practicability of the method lies in its broad substrate adaptability and in its ability to provide a simple green pathway for synthesizing GABAA receptor analogs.
Topics & Concepts
ChemistryElectrochemistryAminationCombinatorial chemistrySubstrate (aquarium)Organic chemistryElectrodeCatalysisOceanographyPhysical chemistryGeologySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques