All-in-one microfluidic assembly of insulin-loaded pH-responsive nano-in-microparticles for oral insulin delivery
Clarinda Costa, Zehua Liu, João P. Martins, Alexandra Correia, Patrícia Figueiredo, Antti Rahikkala, Wei Li, Jani Seitsonen, Janne Ruokolainen, Sami-Pekka Hirvonen, Ana Aguiar‐Ricardo, M. Luísa Corvo, Hélder A. Santos
Abstract
Here, a continuous two-step glass-capillary microfluidic technique to produce a multistage oral delivery system is reported. Insulin is successfully encapsulated into liposomes, which are coated with chitosan to improve their mucoadhesion. The encapsulation in an enteric polymer offers protection from the harsh gastric conditions. Insulin permeability is enhanced across an intestinal monolayer.
Topics & Concepts
MicrofluidicsInsulin deliveryInsulinCapillary actionLiposomeDelivery systemNano-ChemistryNanotechnologyPeptideMaterials scienceBiomedical engineeringDiabetes mellitusInternal medicineBiochemistryMedicineEndocrinologyType 1 diabetesComposite materialAdvanced Drug Delivery SystemsMicrofluidic and Capillary Electrophoresis ApplicationsInnovative Microfluidic and Catalytic Techniques Innovation