Visible-light-induced dehydrogenative amidation of aldehydes enabled by iron salts
Han Gao, Lin Guo, Yining Zhu, Chao Yang, Wujiong Xia
Abstract
A direct dehydrogenative amidation reaction of aldehydes and amines under a visible light mediated ligand-to-metal charge transfer (LMCT) process was described. In this protocol, aldehyde substrates were activated by photoinduced hydrogen atom abstraction (HAA), generating acyl chloride intermediates followed by nucleophilic addition of amines. The synthetic method furnishes good functional group tolerance and broad substrate scope toward both aliphatic and aromatic components.
Topics & Concepts
ChemistryNucleophileAldehydeFunctional groupSubstrate (aquarium)PhotochemistryHydrogen atom abstractionVisible spectrumCombinatorial chemistryLigand (biochemistry)RadicalOrganic chemistryCatalysisOceanographyBiochemistryPolymerOptoelectronicsGeologyPhysicsReceptorRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods