A physiologically-based pharmacokinetic model to describe antisense oligonucleotide distribution after intrathecal administration
Michael Monine, Daniel A. Norris, Yanfeng Wang, Ivan Nestorov
Topics & Concepts
PharmacokineticsSpinal muscular atrophyMedicineNeurosciencePharmacologyIntrathecalAmyotrophic lateral sclerosisCentral nervous systemDistribution (mathematics)Spinal cordBiologyPathologyAnesthesiaDiseaseMathematicsMathematical analysisNeurogenetic and Muscular Disorders ResearchAmyotrophic Lateral Sclerosis ResearchRNA Interference and Gene Delivery