Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Neurodegenerative Diseases
Panpan Yao, Liping Zhou, Lujie Zhu, Binjie Zhou, Qin Yu
Abstract
Neurodegenerative disease is a kind of chronic, progressive nervous system disease characterized by neuron degeneration or apoptosis. Current treatments cannot prevent the development of the disease. Possible alternative treatments include cell therapy, especially with the use of mesenchymal stem cells (MSCs). MSCs are pluripotent stem cells with capacities for self-renewal and multidirectional differentiation. MSCs may serve as a reliable source of neural cells for potential cell replacement therapy or regenerative medicine treatment. Here, we summarized the therapeutic mechanisms of MSCs and how they can contribute to the development of treatments for neurodegenerative diseases.
Topics & Concepts
Mesenchymal stem cellInduced pluripotent stem cellRegenerative medicineStem cellDiseaseStem-cell therapyCell therapyMedicineNeuroscienceBiologyCancer researchPathologyEmbryonic stem cellCell biologyBiochemistryGeneMesenchymal stem cell researchPluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms