A ratiometric fluorescent probe for monitoring pH fluctuations during autophagy in living cells
Shan Wang, Bingya Wang, Lei Zhu, Ji‐Ting Hou, Kang‐Kang Yu
Abstract
We present a ratiometric fluorescent probe for monitoring pH featuring superb photostability and chemostability. The down-regulation of the intracellular pH during autophagy in living cells induced by various stimuli, including several drugs and starvation, was quantified, which could provide instructive value to construct autophagy models to study the related pathological processes.
Topics & Concepts
FluorescenceChemistryAutophagyBiophysicsNanotechnologyPhotochemistryMaterials scienceBiochemistryOpticsBiologyPhysicsApoptosisAutophagy in Disease and TherapyAdenosine and Purinergic SignalingSynthesis of Indole Derivatives