Celastrol ameliorates lipopolysaccharide (LPS)-induced acute lung injury by improving mitochondrial function through AMPK/PGC-1α/Nrf1-dependent mechanism
Xinyu Deng, Jing He, Wenpeng Deng, Wang Deng, Xingyu Zhu, Hao Luo, Daoxin Wang
Topics & Concepts
NRF1LipopolysaccharideAMPKMechanism (biology)ChemistryFunction (biology)AMP-activated protein kinaseMitochondrionCell biologyPharmacologyMedicineImmunologyBiochemistryBiologyPhosphorylationMitochondrial biogenesisPhysicsProtein kinase AQuantum mechanicsNatural Compounds in Disease TreatmentInflammation biomarkers and pathwaysImmune cells in cancer