Dual Nickel/Photoredox‐Catalyzed Asymmetric Carbamoylation of Benzylic C(sp<sup>3</sup>)−H Bonds
Sergio Cuesta‐Galisteo, Johannes Schoergenhumer, Cédric Hervieu, Cristina Nevado
Abstract
-H bonds has become a powerful tool for the asymmetric functionalization of organic feedstocks. Here, we present an asymmetric synthesis of α-aryl amides via carbamoylation of alkylarenes with isocyanates as electrophiles. The synergistic combination of a photoredox and a chiral nickel-catalyst, enables the use of readily available and neutral reagents under mild reaction conditions and provides straightforward access to pharmacologically relevant motifs in enantiomerically pure form.
Topics & Concepts
NickelCatalysisChemistryDual (grammatical number)CrystallographyCombinatorial chemistryPhotochemistryOrganic chemistryArtLiteratureCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques