Iron-catalyzed hydrogen atom transfer induced cyclization of 1,6-enynes for the synthesis of ketoximes: a combined experimental and computational study
Mingming Zhao, Wei He, Liang‐Hua Zou, Dawei Wang, Tian‐Yu Sun, Xiao‐Feng Xia
Abstract
An iron-catalyzed reductive radical cyclization/hydro-oximation of 1,6-enynes with<italic>t</italic>BuONO was developed, leading to functionalized benzofuran, benzothiophene, and cyclopentenyl-based ketoximes.
Topics & Concepts
ChemistryBenzofuranBenzothiopheneCatalysisHydrogen atomCombinatorial chemistryMedicinal chemistryAtom (system on chip)Organic chemistryParallel computingAlkylThiopheneComputer scienceCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques