Global Regulatory Pathways Converge To Control Expression of Pseudomonas aeruginosa Type IV Pili
Kimberly A. Coggan, Matthew G. Higgs, Evan D. Brutinel, Jeremiah N. Marden, Peter J. Intile, Hanne C. Winther‐Larsen, Michael Koomey, Timothy L. Yahr, Matthew C. Wolfgang
Abstract
operon encodes several pilus-associated proteins that are essential for proper Tfp function and surface sensing. In this study, we report that linked but independent regulatory systems dictate Tfp biogenesis. We also demonstrated the importance of different phosphorylation states of the AlgZ/AlgR two-component system and its role in Tfp biogenesis. Overall, this study furthers our understanding of the complex regulatory mechanisms that govern the production of a critical and multifaceted virulence factor.
Topics & Concepts
Pseudomonas aeruginosaVirulencePilusMicrobiologyOpportunistic pathogenPathogenBiologyFimbriaHuman pathogenRepertoirePathogenesisQuorum sensingVirulence factorBacteriaGeneGeneticsImmunologyPhysicsAcousticsBacterial biofilms and quorum sensingAntibiotic Resistance in BacteriaVibrio bacteria research studies