Alkoxy-functionalised dihydropyrimido[4,5-<i>b</i>]quinolinones enabling anti-proliferative and anti-invasive agents
Subham G. Patel, Ira Sharma, Mehul P. Parmar, Joaquina Nogales, Chirag D. Patel, Savan S. Bhalodiya, Disha P. Vala, Niraj V. Shah, Sourav Banerjee, Hitendra M. Patel
Abstract
]quinolinones using a microwave-assisted multicomponent reaction. All the synthesized molecules were screened for anti-proliferative and anti-invasive activity against glioblastoma cells. 5c shows the most potent anti-proliferative activity with a half maximal effective concentration of less than 3 μM against primary patient-derived glioblastoma cells. 5c effectively inhibited invasion and tumor growth of 3D primary glioma cultures in a basement membrane matrix. This suggests that the novel compounds could inhibit both the proliferation and invasive spread of glioma and they were selected for further study.