Calcium influx-induced lytic cell death disrupts skin immune homeostasis
Yingxue Du, Xiangbing Qi, Lei Zhang, Yong Yang, Ting Chen
Abstract
Programmed lytic cell death is crucial in maintaining tissue homeostasis and contributing to pathogenesis. However, our understanding of whether calcium can trigger lytic cell death through calcium-permeable channels responding to environmental stimuli remains limited 1 . TRPV3, a calcium-permeable channel in the cell plasma membrane, is highly expressed in skin keratinocytes—the first line of defense against various physical and chemical environmental stimuli 2 . Here, we found a unique mechanism involving TRPV3-mediated calcium influx-induced lytic cell death in the skin, disrupting skin immune homeostasis.
Topics & Concepts
Lytic cycleCalciumImmune systemHomeostasisProgrammed cell deathCalcium metabolismCell biologyCellChemistryBiologyImmunologyBiochemistryApoptosisOrganic chemistryVirusDermatology and Skin Diseasesmelanin and skin pigmentationAdvancements in Transdermal Drug Delivery