Anti-inflammatory activity of superoxide dismutase mimics functionalized with cell-penetrating peptides
Émilie Mathieu, Anne-Sophie Bernard, H. Y. Vincent Ching, Andréa Somogyi, Kadda Medjoubi, Jennifer Rodon Fores, Hélène Bertrand, Amandine Vincent, Sylvain Trépout, Jean‐Luc Guerquin‐Kern, Andreas Scheitler, Ivana Ivanović‐Burmazović, Philippe Seksik, Nicolas Delsuc, Clotilde Policar
Abstract
, apparent reduction potential and intrinsic superoxide dismutase activity. However, their accumulation in cells is different (Mn1-R9 < Mn1-MPP < Mn1-RW9 < Mn1), as well as their subcellular distribution. In addition, the three functionalized-complexes display a better anti-inflammatory activity than Mn1 when assayed at 10 μM. This improvement is due to a combination of an anti-inflammatory effect of the peptidyl moiety itself, and of the SOD mimic for Mn1-RW9 and Mn1-MPP. In contrast, the enhanced anti-inflammatory activity of Mn1-R9 is solely due to the SOD mimic.