Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice
Jinbo Cheng, Yajin Liao, Yuan Dong, Han Hu, Nannan Yang, Xiangxi Kong, Shuoshuo Li, Xiaoheng Li, Jifeng Guo, Lixia Qin, Jiezhong Yu, Cun‐Gen Ma, Jianke Li, Mingtao Li, Beisha Tang, Zengqiang Yuan
Abstract
: ATG: autophagy related; cAMP: cyclic adenosine monophosphate; cKO: conditional knockout; NOS2/INOS: nitric oxide synthase 2, inducible; IL1B: interleukin 1 beta; ITGAM/CD-11b: integrin alpha M/cluster of differentiation molecule 11B; MAP1LC3: microtubule-associated protein 1 light chain 3; MIF: macrophage migration inhibitory factor (glycosylation-inhibiting factor); NLRP3: NLR family pyrin domain containing 3; PBS: phosphate-buffered saline; PD: parkinson disease; PDE10A: phosphodiesterase 10A; SN: substantial nigra; TH: tyrosine hydroxylase; TNF: tumor necrosis factor; WT: wild type.