Palladium-catalyzed enantioselective decarboxylative allylic alkylation of α-benzyl cyanoacetates: access to chiral acyclic quaternary carbon stereocenters
Qing Bao, Ting-Jia Sun, Yanping Zhang, Zhen‐Hua Wang, Yong You, Zhen-Zhen Ge, Ming‐Qiang Zhou, Jian‐Qiang Zhao, Wei‐Cheng Yuan
Abstract
A palladium-catalyzed enantioselective decarboxylative allylic alkylation of α-benzyl cyanoacetates with methylene cyclic carbamates was developed for the construction of nitrile-containing acyclic quaternary carbon stereocenters with good results.
Topics & Concepts
StereocenterChemistryEnantioselective synthesisAlkylationTsuji–Trost reactionNitrileAllylic rearrangementCatalysisMethylenePalladiumOrganic chemistryAsymmetric Synthesis and CatalysisSynthetic Organic Chemistry MethodsMicrobial Natural Products and Biosynthesis