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Phosphorus-mediated sp2–sp3 couplings for C–H fluoroalkylation of azines

Xuan Zhang, Kyle G. Nottingham, Chirag Patel, Juan V. Alegre‐Requena, Jeffrey N. Levy, Robert S. Paton, Andrew McNally

2021Nature164 citationsDOI

Topics & Concepts

ChemistryPyridineReagentTrifluoromethylMoleculeSteric effectsCombinatorial chemistryFunctional groupPhosphorusPhosphoniumStereochemistryMedicinal chemistryOrganic chemistryAlkylPolymerFluorine in Organic ChemistrySynthesis and Biological EvaluationCyclopropane Reaction Mechanisms
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