Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study
Lei Zhong, Zhipeng Zhao, Xiaonan Zhang
Abstract
Recently, a study by Edwin Cuppen’s group published in Nature depicted the genomic differences between late-stage treated metastatic cancers and early-stage untreated primary cancers via a pan-cancer whole-genome sequencing (WGS) analysis. 1 This study characterizes unique features of metastatic solid tumors and provides a valuable resource for further investigating tumor evolution and treatment resistance.
Topics & Concepts
CancerPrimary cancerBiologyGenomeCancer geneticsGeneticsComputational biologyMedicineOncologyGeneCancer Genomics and DiagnosticsGenetic factors in colorectal cancerLung Cancer Treatments and Mutations