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Red-Light-Induced N,N′-Dipropyl-1,13-dimethoxyquinacridinium-Catalyzed [3+2] Cycloaddition of Cyclopropylamines with Alkenes or Alkynes

Thomas L. Gianetti, Savannah M. Stull, Liangyong Mei

2021Synlett19 citationsDOI

Abstract

Abstract A red-light-mediated [3+2] annulation of cyclopropylamines with akenes or alkynes in the presence of N,N′-dipropyl-1,13-dimethoxyquinacridinium is reported. An array of cyclopentane or cyclopentene derivatives with diverse functional groups have been obtained in moderate to excellent yields under mild conditions.

Topics & Concepts

ChemistryCyclopentaneCyclopenteneCycloadditionAnnulationCatalysisMedicinal chemistryOrganic chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsRadical Photochemical Reactions
Red-Light-Induced N,N′-Dipropyl-1,13-dimethoxyquinacridinium-Catalyzed [3+2] Cycloaddition of Cyclopropylamines with Alkenes or Alkynes | Litcius