Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice

Lin Wang, Dominik Aschenbrenner, Zhiyang Zeng, Xiya Cao, Daniel Mayr, Meera Mehta, Melania Capitani, Neil Warner, Jie Pan, Liren Wang, Li Qi, Tao Zuo, Sarit Cohen‐Kedar, Jiawei Lu, Rico Chandra Ardy, Daniel J. Mulder, Dilan Dissanayake, Kaiyue Peng, Zhiheng Huang, Xiaoqin Li, Yuesheng Wang, Xiaobing Wang, Shuchao Li, Samuel J. Bullers, Anís N. Gammage, Klaus Warnatz, Ana‐Iris Schiefer, Gergely Kriván, Vera Goda, Walter H.A. Kahr, Mathieu Lemaire, Helen Griffin, Sophie Hambleton, Chien-Yi Lu, Iram Siddiqui, Michael G. Surette, Daniel Kotlarz, Karin R. Engelhardt, Helen Griffin, Robert Rottapel, Hélène Decaluwe, Ronald M. Laxer, Michele Proietti, Sophie Hambleton, Suzanne Elcombe, Conghui Guo, Bodo Grimbacher, Iris Dotan, Siew C. Ng, Spencer A. Freeman, Scott B. Snapper, Christoph Klein, Kaan Boztuǧ, Ying Huang, Dali Li, Holm H. Uhlig, Aleixo M. Muise