Evaluation of Antioxidant and Anticancer Activity of Myristica fragrans Houtt. Bark
Binawati Ginting, Mustanir Mustanir M, Nurdin Nurdin N, Maulidna Maulidna M, Murniana Murniana M, Safrina Safrina S
Abstract
This study aims to evaluate the antioxidant and anticancer activity of secondary metabolite compounds from Myristica fragrans Houtt. (nutmeg) bark using n-hexane extract based on DPPH radical scavenging and microculture tetrazolium salt (MTT) assay. The chemical structural analysis using NMR, FTIR, and LC-MS spectroscopy confirmed and identified the structure of isolated compound namely (2E)-5(2z.4E)-hexa-2,4,-dio-zyl)-2propylcyclohexanol (C18H30O4) for the first time which is corresponding for the excellent antioxidant and anticancer activity against MCF-7 cell lines with the IC50 value of 99.76 and 10.75 ppm, respectively.
Topics & Concepts
Myristica fragransDPPHChemistryTraditional medicineNutmegBark (sound)AntioxidantCurcuminoidIC50Food scienceOrganic chemistryBiochemistryIn vitroBiologyMedicineCurcuminEcologyPlant-derived Lignans Synthesis and BioactivityMedicinal Plant ResearchNatural Antidiabetic Agents Studies