Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD)
Matthew Hamilton, Melissa M. Heintz, Marisa Pfohl, Emily Marques, Lucie C. Ford, Angela L. Slitt, William S. Baldwin
Topics & Concepts
SteatosisToxicityEndocrinologyInternal medicineChemistryTransgeneLipid metabolismGenetically modified mouseCYP2B6MetabolismBiologyCytochrome P450MedicineBiochemistryGeneCYP3A4Per- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals