NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging
Sabina Chubanava, Iuliia Karavaeva, Amy M. Ehrlich, Roger M. Justicia, A. Basse, Ivan Kulik, Emilie Dalbram, Danial Ahwazi, Samuel R. Heaselgrave, Kajetan Trôst, Ben Stocks, Ondřej Hodek, Raissa N. Rodrigues, Jesper F. Havelund, Farina Schlabs, Steen Larsen, Caio Yogi Yonamine, Carlos Henríquez‐Olguín, Christian Ludwig, Daniela Giustarini, Ranieri Rossi, Zachary Gerhart‐Hines, Thomas Möritz, Juleen R. Zierath, Kei Sakamoto, Thomas E. Jensen, Nils J. Færgeman, Gareth G. Lavery, Atul S. Deshmukh, Jonas T. Treebak
Abstract
abundance while maintaining tissue integrity and functionality, as demonstrated by preserved muscle morphology, contractility, and exercise tolerance. This absence of functional impairments was further supported by intact mitochondrial respiratory capacity and unaltered muscle transcriptomic and proteomic profiles. Furthermore, lifelong NAD depletion did not accelerate muscle aging or impair whole-body metabolism. Collectively, these findings suggest that NAD depletion does not contribute to age-related decline in skeletal muscle function.