Tumor microenvironment-based screening repurposes drugs targeting cancer stem cells and cancer-associated fibroblasts
Pei-Jung Lee, Chao‐Chi Ho, Hao Ho, Wan-Jiun Chen, Chiu-Hua Lin, Yi‐Hua Lai, Yi‐Chen Juan, Wen-Chung Chu, Jia-Hua Lee, Sheng‐Fang Su, Hsuan‐Yu Chen, Jeremy J.W. Chen, Gee‐Chen Chang, Ker-Chau Li, Pan‐Chyr Yang, Huei‐Wen Chen
Abstract
The TME-based drug screening platform provides a tool to identify and repurpose compounds targeting cancer cells, CSCs and CAFs, which may accelerate drug development and therapeutic application for lung cancer patients.
Topics & Concepts
Cancer stem cellTumor microenvironmentCancer researchCancer cellCancer-Associated FibroblastsCancerIn vivoMetastasisMedicineBiologyInternal medicineBiotechnologyCancer Cells and MetastasisEpigenetics and DNA Methylation3D Printing in Biomedical Research