Simulated hyperglycemia impairs insulin signaling in endothelial cells through a hyperosmolar mechanism
Rosalinda Madonna, Damiana Pieragostino, Cláudia Rossi, Pamela Confalone, Ilaria Cicalini, Ilaria Minnucci, Mirco Zucchelli, Piero Del Boccio, Raffaele De Caterina
Topics & Concepts
Insulin resistanceProtein kinase BEnosPI3K/AKT/mTOR pathwayInsulinDownregulation and upregulationInternal medicineEndocrinologyInsulin receptorChemistrySignal transductionBiologyMedicineNitric oxideBiochemistryNitric oxide synthaseGeneMetabolomics and Mass Spectrometry StudiesAdipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and Lipoproteins